酸化窒素(NO)は２１世紀の新しい抗精神病薬となり得るのか。ニトロプルシッド・ナトリウム（Sodium Nitroprusside）にて統合失調症の症状が改善 カテゴリ: ニトロプルシッド 統合失調症 これが、もし、事実ならば、クロールプロマジン以来の大発見かもしれない。 JAMAの2013年7月に掲載されたばかりの論文を今回は紹介したい。 精神科と麻酔科は関係が深いようだ。麻酔薬の中に精神科治療のヒントが隠されているのかもしれない。クロールプロマジンは麻酔薬からの発見であったが、今回も同じように麻酔の際に使用される薬物からの発見である。うつ病で速効性を発揮するケタミンが同じく麻酔薬（静脈麻酔剤）であったように、今回のニトロプルシッドも麻酔薬からの発見である（手術中の高血圧時の降圧剤として使用する薬剤）。 しかも、ケタミン同様に速効性を発揮し、１回の使用で4週間も効果が持続したようだ。これが事実であれば、凄いことである。そんなことは統合失調症ではこれまで考えられなかったことであるからである。 統合失調症の急性期の症状がニトロプルシッド・ナトリウムの静脈注射によって急速に改善した 「Rapid Improvement of Acute Schizophrenia Symptoms After Intravenous Sodium Nitroprusside」 http://archpsyc.jamanetwork.com/article.aspx?articleid=1686035
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Designing and Refining Ni(II)diimine Catalysts Toward the Controlled Synthesis of Electron-Deficient Conjugated Polymers ACS ActiveView PDF Hi-Res Print, Annotate, Reference QuickView PDF [1439 KB] PDF w/ Links [414 KB] Full Text HTML Abstract Supporting Info -> Figures Reference QuickView Add to ACS ChemWorx Colin R. Bridges † , Theresa M. McCormick † , Gregory L. Gibson † , Jon Hollinger † , and Dwight S. Seferos * † ‡ † Department of Chemistry, Lash Miller Chemical Laboratories, University of Toronto , 80 St. George Street, Toronto, Ontario M5S 3H6, Canada ‡ Department of Chemical Engineering & Applied Chemistry, University of Toronto , 200 College Street, Toronto, Ontario M5S 3E5, Canada J. Am. Chem. Soc. , Article ASAP DOI: 10.1021/ja4073904 Publication Date (Web): August 12, 2013 Copyright © 2013 American Chemical Society dsefero...
Catalytic Hydrogenation Activity and Electronic Structure Determination of Bis(arylimidazol-2-ylidene)pyridine Cobalt Alkyl and Hydride Complexes ACS ActiveView PDF Hi-Res Print, Annotate, Reference QuickView PDF [4474 KB] PDF w/ Links [827 KB] Full Text HTML Abstract Supporting Info -> Figures Reference QuickView Add to ACS ChemWorx Renyuan Pony Yu † , Jonathan M. Darmon † , Carsten Milsmann † , Grant W. Margulieux † , S. Chantal E. Stieber † , Serena DeBeer ‡ § , and Paul J. Chirik * † † Department of Chemistry, Princeton University , Princeton, New Jersey 08544, United States ‡ Max-Planck Institute for Chemical Energy Conversion , Stiftstrasse 34-36, D-45470 Mülheim an der Ruhr, Germany § Department of Chemistry and Chemical Biology, Cornell University , Ithaca, New York 14853, United States J. Am. Chem. Soc. , Article ASAP D...
X-ray Absorption Spectroscopy Proves the Trigonal-Planar Sulfur-Only Coordination of Copper(I) with High-Affinity Tripodal Pseudopeptides ACS ActiveView PDF Hi-Res Print, Annotate, Reference QuickView PDF [1300 KB] PDF w/ Links [364 KB] Full Text HTML Abstract Supporting Info -> Figures Reference QuickView Add to ACS ChemWorx Anne-Solène Jullien † , Christelle Gateau † , Isabelle Kieffer ‡ § , Denis Testemale ‡ , and Pascale Delangle * † † Service de Chimie Inorganique et Biologique (UMR_E 3 CEA UJF), Commissariat à l′Energie Atomique et aux Energies Alternatives, INAC , 17 rue des martyrs, 38054 Grenoble Cedex 9, France ‡ BM30B/FAME beamline, European Synchotron Radiation Facility (ESRF) , F-38043 Grenoble Cedex 9, France § Observatoire des Sciences de l′Université de Grenoble, UMS 832 CNRS Université Joseph Fourier , F-38041 Grenoble Cedex 9, Fra...
PERSPECTIVE CHEMISTRY Copper's Contribution to Amination Catalysis Sherry R. Chemler + Author Affiliations Department of Chemistry, The State University of New York, Buffalo, NY 14260, USA. E-mail: schemler@buffalo.edu Copper complexes are used as catalysts in modern synthetic chemistry because of their low cost, versatile reactivity, and broad tolerance for functional groups on substrates. Oxidation states in copper complexes can range from Cu 0 to Cu IV , and the metal center can participate in either two-electron or single-electron processes, sometimes both in the same catalytic cycle ( 1 – 6 ). This perspective highlights copper's contribution to amination catalysis, specifically the formation of carbon-nitrogen (C–N) bonds by coupling amines or amides with aryl halides (ArX) and alkyl halides (Ullmann-Goldberg reaction), arenes and alkanes [carbon-hydrogen (C–H) bond amination], or alkenes (oxidative amination, aminooxygenation, carboamination,...
Paper Reversible insertion of carbon dioxide into Pt( II )–hydroxo bonds Tracy L. Lohr , a Warren E. Piers * a and Masood Parvez a Show Affiliations Dalton Trans. , 2013, Advance Article DOI: 10.1039/C3DT51701B Received 25 Jun 2013, Accepted 27 Jul 2013 First published online 29 Jul 2013 | | Share on citeulike | Share on facebook | Share on twitter | | More PDF Rich HTML Send PDF to Kindle Download Citation BibTex EndNote MEDLINE ProCite ReferenceManager RefWorks RIS Request Permissions Abstract Cited by Related Content The reactivity of three monomeric diimine Pt( II ) hydroxo complexes, (NN)Pt(OH)R (NN = bulky diimine ligand; R = OH, 1-OH ; R = C 6 H 5 , 1-Ph ; R = CH 3 , 1-Me ) towards carbon dioxide has been investigated. Insertion into the Pt–OH bond...
Paper A Theoretical Study of the Mechanisms of Oxidation of Ethylene by Manganese Oxo Complexes Albert Aniagyei , Richard Tia and Evans Adei Dalton Trans. , 2013, Accepted Manuscript DOI: 10.1039/C3DT51700D Received 25 Jun 2013, Accepted 01 Aug 2013 First published online 02 Aug 2013 | | Share on citeulike | Share on facebook | Share on twitter | | More PDF Rich HTML Send PDF to Kindle Download Citation BibTex EndNote MEDLINE ProCite ReferenceManager RefWorks RIS Request Permissions Abstract Cited by Related Content The mechanisms of oxidation of ethylene by manganese-oxo complexes of the type MnO3L (L= O- , Cl, CH3, OCH3, Cp, NPH3) have been explored on the singlet, doublet, triplet and quartet potential energy surfaces at the B3LYP/LACVP* level of theory and the results disc...