Angewandte Chemie International Edition by Sudip K. Chatterjee, Ram Chandra Maji, Suman Kumar Barman, Marilyn M. Olmstead, Apurba K. Patra / 9h // keep unread // hide // preview Abstract A functional model complex of nickel superoxide dismutase (NiSOD) with a non-peptide ligand which mimics the full catalytic cycle of NiSOD is unknown. Similarly, it has not been fully elucidated whether NiSOD activity is a result of an outer- or inner-sphere electron-transfer mechanism. With this in mind, two octahedral nickel(II)/(III) complexes of a bis-tridentate N 2 S donor carboxamide ligand, N -2-phenylthiophenyl-2′-pyridinecarboxamide (HL Ph ), have been synthesized, structurally characterized, and their SOD activities examined. These complexes mimic the full catalytic cycle of NiSOD. Electrochemical experiments support an outer-sphere electron-transfer mechanism for their SOD activity. Copy cat : Hexacoordinate nickel(II)/(III) complexes are prepared which mimic t