Itoh Group Literature Review

Sohini Mukherjee , Arnab Mukherjee , Ambika Bhagi-Damodaran , Manjistha Mukherjee , Yi Lu & Abhishek Dey Nature Communications 6 , Article number : 8467 doi:10.1038/ncomms9467 Received 15 December 2014 Accepted 24 August 2015 Published 12 October 2015  http://www.nature.com/ncomms/2015/151012/ncomms9467/full/ncomms9467.html Abstract Creating an artificial functional mimic of the mitochondrial enzyme cytochrome c oxidase (C c O) has been a long-term goal of the scientific community as such a mimic will not only add to our fundamental understanding of how C c O works but may also pave the way for efficient electrocatalysts for oxygen reduction in hydrogen/oxygen fuel cells. Here we develop an electrocatalyst for reducing oxygen to water under ambient conditions. We use site-directed mutants of myoglobin, where both the distal Cu and the redox-active tyrosine residue present in C c O are modelled. In situ Raman spectroscopy shows that this catalyst fe...

Yoann Roux , Rémy Ricoux , Frédéric Avenier & Jean-Pierre Mahy Nature Communications 6, Article number : 8509 doi:10.1038/ncomms9509 Received 28 June 2015 Accepted 28 August 2015 Published 30 September 2015    http://www.nature.com/ncomms/2015/150930/ncomms9509/full/ncomms9509.html Abstract Development of artificial systems, capable of delivering electrons to metal-based catalysts for the reductive activation of dioxygen, has been proven very difficult for decades, constituting a major scientific lock for the elaboration of environmentally friendly oxidation processes. Here we demonstrate that the incorporation of a flavin mononucleotide (FMN) in a water-soluble polymer, bearing a locally hydrophobic microenvironment, allows the efficient reduction of the FMN by NADH. This supramolecular entity is then capable of catalysing a very fast single-electron reduction of manganese(III) porphyrin by splitting the electron pair issued from NADH...