Oscar Pàmies,a,* Montserrat Diéguez,a,* and Jan-E. Bäckvallb,*
a Departament de QuÌmica FÌsica i Inorg‡nica, Universitat Rovira i Virgili, Campus Sescelades, C/Marcel·lÌ Domingo, s/n. 43007 Tarragona, Spain Fax: (+34)-97-755-9563; phone: (+34)-97-755-8780; e-mail: oscar.pamies@urv.cat or montserrat.dieguez@urv.cat
b Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden Fax: (+46)-(0)8-154-908; phone: (+46)-(0)8-674-7178; e-mail: jeb@organ.su.se
Received: March 24, 2015; Revised: April 27, 2015; Published online: May 12, 2015 DOI: 10.1002/adsc.201500290
a Departament de QuÌmica FÌsica i Inorg‡nica, Universitat Rovira i Virgili, Campus Sescelades, C/Marcel·lÌ Domingo, s/n. 43007 Tarragona, Spain Fax: (+34)-97-755-9563; phone: (+34)-97-755-8780; e-mail: oscar.pamies@urv.cat or montserrat.dieguez@urv.cat
b Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden Fax: (+46)-(0)8-154-908; phone: (+46)-(0)8-674-7178; e-mail: jeb@organ.su.se
Received: March 24, 2015; Revised: April 27, 2015; Published online: May 12, 2015 DOI: 10.1002/adsc.201500290
http://onlinelibrary.wiley.com/doi/10.1002/adsc.201500290/full
Abstract : Artificial metalloenzymes combine the excellent selective recognition/binding properties of enzymes with transition metal catalysts, and therefore many asymmetric transformations can benefit from these entities. The search for new successful strategies in the construction of metal-enzyme hybrid catalysts has therefore become a very active area of research. This review discusses all the developed strategies and the latest advances in the synthesis and application in asymmetric catalysis of artificial metalloenzymes with future directions for their design, synthesis and application (Sections 2–4). Finally, advice is presented (to the non-specialist) on how to prepare and use artificial metalloenzymes (Section 5).
Abstract : Artificial metalloenzymes combine the excellent selective recognition/binding properties of enzymes with transition metal catalysts, and therefore many asymmetric transformations can benefit from these entities. The search for new successful strategies in the construction of metal-enzyme hybrid catalysts has therefore become a very active area of research. This review discusses all the developed strategies and the latest advances in the synthesis and application in asymmetric catalysis of artificial metalloenzymes with future directions for their design, synthesis and application (Sections 2–4). Finally, advice is presented (to the non-specialist) on how to prepare and use artificial metalloenzymes (Section 5).
1 Introduction
2 Redesigning Naturally Occurring Metalloenzymes
3.2 Artifical Metalloenzymes via Covalent Anchoring
3.3 Artifical Metalloenzymes via Non-Covalent/ Supramolecular Anchoring
4 Hybrid Catalysts with Metalloenzyme-Like Properties
5 Entry Points to the Preparation and Use of Ar- tificial Metalloenzymes
6 Future Perspectives and Conclusions
Keywords : artificial metalloenzymes ; asymmetric catalysis; hybrid catalysts
3 Creation of New Metalloenzymes from Metal- Free Enzymes
3.1 Artifical Metalloenzymes via Direct Metal Salt Complexation
3.3 Artifical Metalloenzymes via Non-Covalent/ Supramolecular Anchoring
4 Hybrid Catalysts with Metalloenzyme-Like Properties
5 Entry Points to the Preparation and Use of Ar- tificial Metalloenzymes
6 Future Perspectives and Conclusions
Keywords : artificial metalloenzymes ; asymmetric catalysis; hybrid catalysts
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