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Aldehyde-Assisted Ruthenium(II)-Catalyzed CH Oxygenations

投稿者: Yuma Morimoto

Angewandte Chemie International Edition by Fanzhi Yang, Karsten Rauch, Katharina Kettelhoit, Lutz Ackermann  /  2h  //  keep unread  //  hide  //  preview

Abstract

Versatile ruthenium(II) complexes allow for site-selective CH oxygenations with weakly-coordinating aldehydes. The challenging CH functionalizations proceed with high chemoselectivity by rate-determining CH metalation. The new method features an ample substrate scope, which sets the stage for the step-economical preparation of various bioactive heterocycles.
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The weakest link: Challenging aryl CH oxygenations with very weakly coordinating aldehydes proceed chemoselectively in the presence of versatile ruthenium(II) catalysts under mild reaction conditions. This transformation features an ample substrate scope and excellent positional selectivity.

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2014年9月9日 16:15
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