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Dehydrogenative N-Incorporation: A Direct Approach to Quinoxaline N-Oxides under Mild Conditions

投稿者: Yuma Morimoto

Angewandte Chemie International Edition by Feng Chen, Xiaoqiang Huang, Xinyao Li, Tao Shen, Miancheng Zou, Ning Jiao  /  2h  //  keep unread  //  hide  //  preview

Abstract

An efficient method for the synthesis of quinoxaline N-oxides proceeds by the dehydrogenative N-incorporation of simple imines by C(sp2)H and C(sp3)H bond functionalization. The overall transformation involves the cleavage of three CH bonds. The reaction is easily handled and proceeds under mild conditions. Simple and readily availabletert-butyl nitrite (TBN) was employed as the NO source.
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The dehydrogenative incorporation of a nitrogen atom for the synthesis of quinoxaline N-oxides through the functionalization of one C(sp2)H bond and two C(sp3)H bonds in imines proceeds under transition-metal-free conditions. Simple and readily available tert-butyl nitrite (TBN) was employed as the NO source.
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