The Catalytically Active Copper-Amyloid-Beta State: Coordination Site Responsible for Reactive Oxygen Species Production^†

1. Laure-Estelle Cassagnes^1,2, 
2. Vincent Hervé^1,2, 
3. Prof.Dr. Françoise Nepveu^1,2,
4. Dr. Christelle Hureau^3,4, 
5. Prof.Dr. Peter Faller^3,4,*, 
6. Dr. Fabrice Collin^1,2,*

Keywords:

• amyloid-beta peptide;
• copper;
• mass spectrometry;
• reactive oxygen species;
• redox chemistry

Copper-amyloid-β ROS production: Copper ions (red sphere, see picture) have been found to accumulate in amyloid-β plaques and play a role in the generation of reactive oxygen species (ROS) within this context. Mass spectrometry studies were able to detail the sites of oxidation damage and shed new light on the mechanism of ROS production, important for the understanding of the pathogenicity of amyloid-β peptides.

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