Abstract
The importance of aromatic C![[BOND]](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vE-GgA_uIhql9IMq-_RDr8UfoYzgur_HjVEqCupODMDh7LZcU8DJ814vJfson50C6YYKsl1klPSGfKRiDrQdw4JjNnSXF8jOQJFT5tLS4gU5vRxLAP3U5_24zMczJPIgdzIBb0Nahtpk7Dnw=s0-d)
O, CN, and CS bonds necessitates increasingly efficient strategies for their formation. Herein, we report a biomimetic approach that converts phenolic CH bonds into CO, CN, and CS bonds at the sole expense of reducing dioxygen (O2) to water (H2O). Our method hinges on a regio- and chemoselective copper-catalyzed aerobic oxygenation to provide ortho-quinones. ortho-Quinones are versatile intermediates, whose direct catalytic aerobic synthesis from phenols enables a mild and efficient means of synthesizing polyfunctional aromatic rings.
O, CN, and CS bonds necessitates increasingly efficient strategies for their formation. Herein, we report a biomimetic approach that converts phenolic CH bonds into CO, CN, and CS bonds at the sole expense of reducing dioxygen (O2) to water (H2O). Our method hinges on a regio- and chemoselective copper-catalyzed aerobic oxygenation to provide ortho-quinones. ortho-Quinones are versatile intermediates, whose direct catalytic aerobic synthesis from phenols enables a mild and efficient means of synthesizing polyfunctional aromatic rings.
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